New publication: Local heroes or villains: tissue-resident memory T cells in human health and disease


Unlike classical T cells, tissue-resident memory T cells (TRM) do not circulate through blood and lymph and instead have adapted to long-term life in host tissue.

My colleagues Claire Gordon, Susan Christo, Paul Klenerman and Laura Mackay and I recently published this review article on human TRMs including phenotype, function and their role in promoting anti-tumour and anti-infectious immunity while playing pathogenic roles in autoimmune disorders, best described in the skin.

Link to article here.


Breaking News: Subcapsular proliferative foci


New work published by Moran et al from the Phan lab at the Garvan Institute in Sydney, Australia describes a new lymph-node structure: the supcapsular proliferative foci. This structure runs longitudinally and is a hot-bed for memory-B-cell activation upon antigen-re-exposure and plays an important role in the generation of plasma cells.


Click image or here for link.


Call for notes!


Are you a medical student, basic physician trainee or Immunology/Immunopathology advanced trainee who is studying Immunology?

We are looking to boost the content of the notesonimmunology website.

If you have made original study notes that you think could be of benefit to others we would love to add you as a contributor.

Please send the notes in MS Word or Powerpoint to ssas7805@med.usyd.edu.au . Be sure to acknowledge the original source of any figures and tables and to include your name on your work.

notesonimmunology is a free, online, collaborative resource that is not for profit. There is no renumeration for contributions, however you will be listed as a contributor on the website.


Major advance in neuroimmunology: lymphatic vessels supplying brain’s dural sinuses are found


The brain has long been considered a “sanctuary site” from the immune system, influencing our understanding of autoimmune and neuroinflammatory conditions such as multiple sclerosis, encephalitis, neurosarcoidosis and even primary and secondary malignancies. A recent letter to Nature journal has found evidence of lymphatic vessels supplying the brain’s dural sinuses, a finding likely to make a big impression in the neuroimmunology field