Unlike classical T cells, tissue-resident memory T cells (TRM) do not circulate through blood and lymph and instead have adapted to long-term life in host tissue.
My colleagues Claire Gordon, Susan Christo, Paul Klenerman and Laura Mackay and I recently published this review article on human TRMs including phenotype, function and their role in promoting anti-tumour and anti-infectious immunity while playing pathogenic roles in autoimmune disorders, best described in the skin.
Link to article here.
New work published by Moran et al from the Phan lab at the Garvan Institute in Sydney, Australia describes a new lymph-node structure: the supcapsular proliferative foci. This structure runs longitudinally and is a hot-bed for memory-B-cell activation upon antigen-re-exposure and plays an important role in the generation of plasma cells.
Click image or here for link.
My colleagues and I just published a new paper regarding diagnostic methods for Cardiac Sarcoidosis. Patients may have normal imaging on gadolinium-enhanced MRI. If suspicion remains we would suggest progressing to PET.
Report of 2 cases and review of the literature here: