New publication: Local heroes or villains: tissue-resident memory T cells in human health and disease


Unlike classical T cells, tissue-resident memory T cells (TRM) do not circulate through blood and lymph and instead have adapted to long-term life in host tissue.

My colleagues Claire Gordon, Susan Christo, Paul Klenerman and Laura Mackay and I recently published this review article on human TRMs including phenotype, function and their role in promoting anti-tumour and anti-infectious immunity while playing pathogenic roles in autoimmune disorders, best described in the skin.

Link to article here.


Breaking News: Subcapsular proliferative foci


New work published by Moran et al from the Phan lab at the Garvan Institute in Sydney, Australia describes a new lymph-node structure: the supcapsular proliferative foci. This structure runs longitudinally and is a hot-bed for memory-B-cell activation upon antigen-re-exposure and plays an important role in the generation of plasma cells.


Click image or here for link.


New publication: Cardiac Sarcoidosis


My colleagues and I just published a new paper regarding diagnostic methods for Cardiac Sarcoidosis. Patients may have normal imaging on gadolinium-enhanced MRI. If suspicion remains we would suggest progressing to PET.

Report of 2 cases and review of the literature here: