RCPA Part I Written Exam

This page contains links to study notes for the RCPA Immunopathology Part I written exam.

Basic Science:

In regard to studying basic science for the written examination I recommend reading Cellular and Molecular Immunology by Abbas et al cover-to-cover. This will provide a solid foundation of immunology at a molecular level and also highlights relevance to immunopathology and clinical immunology and allergy.

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Allergy:

Specific IgE measurement

Tryptase and ECP

Autoimmunity:

Anti-Adrenal Ab

Antibodies in IBD

Antiphospholipid Abs

Autoimmune liver disease

Autoimmune thyroid disease

Coeliac disease

dsDNA Ab

ENA

Myasthenia gravis

Onconeural Antibodies and Limbic Encephalitis

RF and CCP

Immunodeficiency:

ALPS

APECED and IPEX

Chronic Mucocutaneous Candidiasis

Class Switch Recombination Deficiencies

CVID

HIV Diagnostic Tests

HIV Western Blots

Hyper IgE Syndrome

IgG subclass deficiency

Immunoglobulin levels and function

Lymphocyte subsets

MSMD

Neutrophil disorders

Neutrophil functional assays

NK Cell Disorders

Specific Antibody Deficiency

T-cell Primary Immunodeficiencies

XLP

Laboratory Assays:

Agglutination Assays

B cell clonal disorders

B-CLL Prognostic Markers

Cell Culture Techniques

Cell suspension

CFSE

Complement

ELISA

EPG and IFE

Flow cytometer performance

Flow cytometry of normal tissues and fluids

Flow Cytometry Principles

Fluorescent and chemiluminescent Immunoassays

Gel Electrophoresis

HLA Typing

HLA Typing in Immunological Disease

Immunoglobulin levels and function

Immunoprecipitation

Labelling polyclonal and monoclonal antibodies

Light Chain Disorders and SFLC

Luminex

Lymphocyte enumeration

Lymphocyte subsets

Molecular Techniques

NK LGL

NK Cell Lineage Markers

Polyclonal anti-sera

RIA

T-cell functional assays

Statistics and QC:

Assessing assay performance

Diagnostic application of assay results

Levy-Jennings and CUSUM

Measurement of uncertainty

Reference ranges

Tools to compare two assays

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