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New publication: Local heroes or villains: tissue-resident memory T cells in human health and disease

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Unlike classical T cells, tissue-resident memory T cells (TRM) do not circulate through blood and lymph and instead have adapted to long-term life in host tissue.

My colleagues Claire Gordon, Susan Christo, Paul Klenerman and Laura Mackay and I recently published this review article on human TRMs including phenotype, function and their role in promoting anti-tumour and anti-infectious immunity while playing pathogenic roles in autoimmune disorders, best described in the skin.

Link to article here.

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Breaking News: Subcapsular proliferative foci

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New work published by Moran et al from the Phan lab at the Garvan Institute in Sydney, Australia describes a new lymph-node structure: the supcapsular proliferative foci. This structure runs longitudinally and is a hot-bed for memory-B-cell activation upon antigen-re-exposure and plays an important role in the generation of plasma cells.

 

Click image or here for link.

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Call for notes!

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Are you a medical student, basic physician trainee or Immunology/Immunopathology advanced trainee who is studying Immunology?

We are looking to boost the content of the notesonimmunology website.

If you have made original study notes that you think could be of benefit to others we would love to add you as a contributor.

Please send the notes in MS Word or Powerpoint to ssas7805@med.usyd.edu.au . Be sure to acknowledge the original source of any figures and tables and to include your name on your work.

notesonimmunology is a free, online, collaborative resource that is not for profit. There is no renumeration for contributions, however you will be listed as a contributor on the website.

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notesonimmunology : 2017 wrap-up

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2017 was our busiest year here at notesonimmunology with over 2100 views from all over the world.

Our top 5 countries represented were:

  1. Australia
  2. USA
  3. India
  4. Saudi Arabia
  5. Egypt

The most accessed pages this year were:

  1. MCQ
  2. RCPA Part I Written Exam
  3. Tips on passing the RACP exam
  4. Nephelometry and IgG subclasses
  5. IPEX syndrome

 

Our biggest upload in 2017 was in relation to the RCPA Part I Written and Part II Viva exams.

Thank you for being a part of notesonimmunology in 2017. Wishing you a safe and happy holiday season and looking forward to more immunological banter in 2018.

 

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New publication: Cardiac Sarcoidosis

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My colleagues and I just published a new paper regarding diagnostic methods for Cardiac Sarcoidosis. Patients may have normal imaging on gadolinium-enhanced MRI. If suspicion remains we would suggest progressing to PET.

Report of 2 cases and review of the literature here:

https://jmedicalcasereports.biomedcentral.com/articles/10.1186/s13256-017-1453-6