Unlike classical T cells, tissue-resident memory T cells (TRM) do not circulate through blood and lymph and instead have adapted to long-term life in host tissue.
My colleagues Claire Gordon, Susan Christo, Paul Klenerman and Laura Mackay and I recently published this review article on human TRMs including phenotype, function and their role in promoting anti-tumour and anti-infectious immunity while playing pathogenic roles in autoimmune disorders, best described in the skin.
Link to article here.
notesonimmunology 