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The class of antiretrovirals that acts at the step indicated by the large red arrow is:
c) Fusion inhibitors
d) Protease Inhibitors
e) Integrase inhibitors
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My colleagues and I just published this case report that illustrates the difficulty in diagnosing multicentric Castleman’s disease.
Click here to read
A patient is newly diagnosed with HIV infection. CD4+ T-cell count is 700 cells/microL (RR 500-1200) and HIV viral load is >1000000 copies/mL. In regard to management which statement is CORRECT?
a) There are benefits to commencing Anti-retroviral therapy (ART) when CD4+ T-cell count is >500 cells/mL.
b) If the virus is CCR5-tropic then Maraviroc should be prescribed
c) The patient should be advised to take ART on alternate months i.e. 1 month on therapy and 1 month off
d) The patient should be commenced on PJP prophylaxis
e) The patient is an elite controller
Click here for Answer
Recent interim analysis of the START trial found a clear advantage to early treatment of HIV as opposed to differed treatment. These results will likely have big implications for how HIV is managed globally.
A recent review article I co-authored on the application of zinc-finger nucleases to edit the HIV co-receptor CCR5. Pointing the way to drug free control of HIV?
It has been a great privilege to be involved in this research which found undetectable HIV RNA and DNA in two HIV-infected patients who underwent BMT with donor cells not screened for CCR5 status.